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  • ACE-031 (Myostatin Inhibitor) | 1mg x 10 Vials Kit | >99% Purity

ACE-031 (Myostatin Inhibitor) | 1mg x 10 Vials Kit | >99% Purity

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Chemical Specifications
Product Name ACE-031 (Soluble ActRIIB-IgG1 Fusion Protein)
CAS Number 1168058-20-3 (Ramatercept)
Protein Structure Extracellular domain of human Activin Receptor Type IIB (ActRIIB) fused to the Fc domain of human IgG1
Primary Target High-affinity decoy for Myostatin (GDF-8) and other TGF-β ligands
Molecular Weight ~110.0 kDa (110,000 g/mol) as a homodimer
Purity ≥ 98.0% (Verified by SDS-PAGE & SEC-HPLC)
Appearance White Lyophilized Powder
Storage Store at -20°C to -80°C (Protect from light and moisture)
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          Description
          🎭

          What is ACE-031?

          ACE-031 (Ramatercept) is not a simple peptide; it is a highly complex, 110 kDa soluble recombinant fusion protein universally known in advanced research as “The Ultimate Decoy.” Supplied in elite 1mg x 10 Vials research kits, ACE-031 was masterfully engineered to solve the biological limit of muscle growth. It does this by perfectly mimicking the ActRIIB receptor—the exact receptor that Myostatin (GDF-8) binds to in order to halt muscle proliferation. By flooding the bloodstream with these “fake” receptors, ACE-031 acts as a molecular sponge, intercepting and neutralizing Myostatin before it can ever reach a real muscle cell. This effectively “cuts the brake lines” of genetic limitation, unlocking an environment of infinite hypertrophy and rapid, unhindered skeletal muscle mass accumulation.

          Key Features & Research Protocols

          🛑

          GDF-8 Interception

          The definitive Myostatin blocker. It physically binds to and locks away circulating GDF-8, completely preventing the inhibitory ligand from sending “stop growing” signals to muscle tissue.

          🎭

          The Decoy Mechanism

          Functions by deception rather than stimulation. It provides a false target (a soluble ActRIIB receptor) that is so structurally perfect, Myostatin preferentially binds to it instead of the actual muscle cells.

          💥

          Infinite Hypertrophy Potential

          By removing the genetic “brakes,” ACE-031 allows anabolic pathways (like Akt/mTOR) to run wild. Researchers observe explosive proliferation of satellite cells and profound increases in muscle cross-sectional area.

          🧬

          Giant Fusion Protein Structure

          An engineering marvel. It fuses the extracellular domain of the human ActRIIB receptor directly onto the Fc portion of a human IgG1 antibody, creating a massive, stable 110 kDa homodimer.

          ⏳

          Extended Half-Life (IgG1 Fc)

          The addition of the IgG1 Fc base is a game-changer. It prevents the kidneys from quickly filtering the protein, granting ACE-031 an exceptionally long half-life in the bloodstream for sustained Myostatin suppression.

          💎

          Verified High Purity (>98%)

          Purified via advanced Size-Exclusion Chromatography (SEC-HPLC). Guaranteed to deliver intact, fully-folded homodimers necessary for high-affinity ligand binding in critical in-vitro and in-vivo assays.

          How It Works: Cutting the Genetic Brakes

          To grasp the sheer nuclear power of ACE-031, you must understand the enemy it was designed to defeat: Myostatin (GDF-8). Myostatin is a protein produced by your own body with a single, brutal purpose—to stop your muscles from growing too large. It travels through the blood and binds to the ActRIIB receptors located on the surface of your muscle cells. Once connected, it triggers the Smad2/3 signaling cascade, forcing the muscle cell to shut down protein synthesis and initiate atrophy.

          ACE-031 is the ultimate act of biological espionage. Scientists literally cut off the “lock” (the ActRIIB receptor) from the outside of the muscle cell and attached it to an immune system “boat” (the IgG1 antibody base). When you introduce ACE-031 into a research model, millions of these fake receptors begin circulating freely in the bloodstream.

          When Myostatin is released, it is immediately tricked. It binds to the circulating ACE-031 “Decoys” instead of the real receptors on the muscle tissue. ACE-031 traps the Myostatin like a sponge, completely neutralizing it. Because the real muscle cells are no longer receiving the “stop growing” signal, the genetic brakes are entirely removed. The cells’ natural anabolic pathways (Akt/mTOR) are unleashed at maximum capacity, driving satellite cell division and leading to a state of extreme, unchecked muscular hypertrophy that pushes far beyond natural biological limits.

          🧪 What’s In The Kit

          • Active Compound: ACE-031 Fusion Protein
          • Structure: Soluble ActRIIB-IgG1 Homodimer
          • Format: 10-Vial Research Kit
          • Net Contents: 1mg per vial (10mg total)
          • Purity: ≥98.0% (SEC-HPLC Verified)

          👩‍🔬 Who Uses It

          • Extreme Hypertrophy & Muscle Mass Researchers
          • Muscular Dystrophy (DMD) Investigators
          • Cachexia & Wasting Disease Specialists
          • TGF-β Pathway Analysts
          • Gene Limit & Satellite Cell Scientists

          🔗 Best Paired With

          • Sterile Bacteriostatic Water (BAC)
          • IGF-1 LR3 (To maximize the newly unlocked growth limit)
          • GHRPs / CJC-1295 (For systemic GH synergy)
          • High-protein cell culture environments